Implications of the Neurexin Gene Family in Autism Spectrum Disorder

The neurexin gene family, consisting of NRXN1, NRXN2 and NRXN3 are presynaptic cell adhesion molecules receptors that needed in the development differentiation synaptic function neural development. When microdeletions loss variations expressed, they can encode proteins result disruptions disrupted neurotransmission, leading to a higher risk for developmental disorders neuropsychiatric conditions. NRXN genes strong candidate linked ASD susceptibility, with all three noted as high confidence factors according SFARI Gene Database. In this review, we will go over case studies mutations individuals, explain results provide insight into incomplete penetrance further areas support.